Endocrine Abstracts

Introduction: Most brand-name drugs do not differ that much from their generic counterparts, so switching between the two is not an issue. Levothyroxine, however, is an exception. The question of generic equivalency of levothyroxine products has remained unanswered for several decades. The purpose of the present study was to learn whether there is a difference of dosage between brand-name and generic levothyroxine in patient with well controlled primary hypothyroidism<p cl...

Introduction: Insulin resistance is classically a feature of type 2 diabetes mellitus (T2D). It may also develop among patients with type 1 diabetes (T1D) increasing the risk of cardiovascular mortality. Metabolic syndrome (MS) reflects a state of IR. The aim of this study was to assess the frequency of MS in a population of young adults with T1D and compare it to healthy controls.Methods: We conducted a case control study including 68 T1D patients and 6...

Introduction: DiGeorge syndrome (DGS) is mainly characterized by congenital heart defects, dysmorphic features, hopolasia of the thymus and parathyroid glands and immunodeficiency. Approximately 10% of patients with DGS have autoimmune disease1. Observation: This is a 21-year-old patient, diagnosed with DGS at the age of 14 year old. The diagnosis was suspected on the association of characteristic facial, hypoparathyroidism and a congenital he...

Introduction: Insulinomas are rare pancreatic endocrine tumors causing severe hypoglycemia in non-diabetic patients. We report a case of a rare association between insulinoma and type 2 diabetes.Presentation of the case: A 65-year-old diabetic patient presented with a one year history of recurrent hypoglycemia even after the withdrawal of antidiabetic drugs. First, a functional hypoglycemia was suspected and an oral glucose tolerance test showed hypoglyc...

Introduction: Hashimoto’s thyroiditis is the most frequent cause of hypothyroidism with a relative increased risk of thyroid lymphoma compared to healthy subjects. Hyperfunctioning nodules are rarely malignant. We report the case of a rare association of thyroid carcinoma, a hyperfunctioning nodule and Hashimoto thyroiditis.Observation: We report the case of a 40-year-old female patient treated with L-thyroxine for hypothyroidism due to Hashimoto th...

Introduction: Congenital Hypothyroidism is the principal cause of preventable mental retardation. It is due to Thyroid dysgenesis in 85% of the cases and in 15% to thyroid dyshormonogenesis.Methods: We conducted a prospective study including 17 patients with familial congenital hypothyroidism due to thyroid dyshormonogenesis other than the features of thyroid gland by ultrasound. Other than the phenotype we evaluated the functionality by thyroid Scintigr...

Introduction: Thyroid dyshormonogenesis represents 15% of congenital hypothyroidism. It is a genetic disorder due to a trouble of Thyroid hormones synthesis. it implies many factors involved in this process mainly TPO Enzyme and NIS channel.Methods: We conducted a prospective study including 17 patients with Congenital Hypothyroidism belonging to 4 consanguine multigenerational Tunisian families. The thyroid dyshormonogenesis was diagnosed based on clini...

Introduction: Lymphangioma is a rare benign malformation of the lymphatic system that typically affects the neck and head during childhood. Adrenal glands are an uncommon and rare location for lymphangioma. Herein, we report an unusual clinical presentation of an adrenal lymphangioma revealed by Cushing syndrome.Case report: A 69-year-old female was referred to our department for exploration of an adrenal incidentaloma. Her medical history was positive f...